"immunophenotypic_variation_SEC.csv" is a minimal data set, containing the data at the basis of the results reported in Frontiers of Immunology.
Data including calendary dates can additionally be requested via data_UMR or email at trafo@[1] or westhoff@[2] (upon reasonable request).
[1]uni-marburg.de
[2]med.uni-marburg.de

Variable Names: Short Description

Metastasierung_SLN_Text:	type of metastasis for SLN, keine Metastase = no metastasis, isolierte Tumorzellen (ITC) = isolated tumor cells, Mikrometastase = micrometastasis, Makrometastase = macrometastasis
Metastasierung_NSLN_Text:	type of metastasis for NSLN, keine Metastase = no metastasis, Mikrometastase = micrometastasis, Makrometastase = macrometastasis
tumorart_text:			tumor type, NST = invasive carcinoma NST, ILC = invasive lobular carcinoma, other = other types
Tumorart_Text:			tumor type, NST = invasive carcinoma NST, ILC = invasive lobular carcinoma, apokrin = apocrine, metaplastisch = metaplastic, muzinoes = mucinous, papillaer = papillary, tubulaer = tubular carcinoma
Groesse PT [mm]:		size of primary tumor in mm
Groesse_PT_bin:			tumor size categorized according to cutoff (29 mm) generated with the tool Cutoff Finder, Tumor < 29 mm = tumor size < 29 mm, Tumor > 29 mm = tumor size > 29 mm
pT_Stadium:			pT stage
pT_bin:				pT stage as binary variable (pT1 vs. pT2/3)
pN_Stadium			pN stage
pN_bin				pN stage as categorized variable (pN0 vs. pN1 vs. pN2/3)
pN_bin_2			pN stage as binary variable (pN0 vs. pN+)
Grading:			grading
ER:				status of estrogen receptor (negative = ER IRS <=1, positive = ER IRS >= 2) 
ER_ IRS:			estrogen receptor expression as IRS (Remmele Score)
PR				status of progesterone receptor (negative = PR IRS <=1, positive = PR IRS >= 2) 
PR_ IRS:			progesterone receptor expression as IRS (Remmele Score)
Her2_neu:			HER2/neu status, negative = 0, positive = 1
positive Flaeche CD31_sq_mm:	positive area of subcapsular sinus for CD31 in mm, as assessed by QuPath
positive Flaeche D2-40_sq_mm:	positive area of subcapsular sinus for D2-40 in mm, as assessed by QuPath
positive Flaeche Prox1_sq_mm:	positive area of subcapsular sinus for Prox1 in mm, as assessed by QuPath
Quotient D2-40 / CD31:		quotient of positive area of subcapsular sinus for D2-40 in mm by positive area of subcapsular sinus for CD31 in mm
Quotient_D240_CD31_bin:		quotient of D2-40 by CD31 categorized according to cutoff (0.037) generated with the tool Cutoff Finder, Quotient D2-40/CD31 < 0.037 = quotient < 0.037, Quotient D2-40/CD31 > 0.037 = quotient > 0.037
Quotient D2-40 / Prox1:		quotient of positive area of subcapsular sinus for D2-40 in mm by positive area of subcapsular sinus for Prox1 in mm
Quotient_D240_Prox1_bin:	quotient of D2-40 by Prox1 categorized according to cutoff (1.5) generated with the tool Cutoff Finder, Quotient D2-40/Prox1 < 1.5 = quotient < 1.5, Quotient D2-40/Prox1 > 1.5 = quotient > 1.5
Gesamtflaeche CD31_sq_mm:	total area of subcapsular sinus for measuring CD31 in mm, as assessed by QuPath
Gesamtflaeche D2-40_sq_mm:	total area of subcapsular sinus for measuring D2-40 in mm, as assessed by QuPath
Gesamtflaeche Prox1_sq_mm:	total area of subcapsular sinus for measuring Prox1 in mm, as assessed by QuPath
ZV_OS:				censoring variable, 0 = alive, 1 = dead
ER_IRS_bin:			ER IRS categorized according to cutoff (ER IRS 7) generated with the tool Cutoff Finder
pos_Flaeche_D240_bin_engl:	positive area of subcapsular sinus for D2-40, categorized according to cutoff (0.009487 mm2) generated with the tool Cutoff Finder
pos_Flaeche_Prox1_bin_engl:	positive area of subcapsular sinus for Prox1, categorized according to cutoff (0.04787 mm2) generated with the tool Cutoff Finder
pos_Flaeche_CD31_bin_engl:	positive area of subcapsular sinus for CD31, categorized according to cutoff (0.6859 mm2) generated with the tool Cutoff Finder
Gesamtflaeche_CD31_bin_engl:	total area of subcapsular sinus for measuring CD31, categorized according to cutoff (0.5384 mm2) generated with the tool Cutoff Finder
Gesamtflaeche_D240_bin_engl:	total area of subcapsular sinus for measuring D2-40, categorized according to cutoff (0.7399 mm2) generated with the tool Cutoff Finder
Gesamtflaeche_Prox1_bin_engl:	total area of subcapsular sinus for measuring Prox1, categorized according to cutoff (0.9375 mm2) generated with the tool Cutoff Finder
TILs_metastasis:		stromal TILs assessed in metastasis, in %
ln_activation:			status of lymph node activation
OS_Zeit_Jahre:			time of overall survival in years, time between date of surgery and date of death or last vital status
Alter_OP_Jahre:			age at surgery (in years)
Alter_OP_bin:			age at surgery in years, categorized according to cutoff (60)	
TILs_bin:			stromal TILs assessed in metastasis in %, categorized according to cutoff (4 %)
ln_activation_bin:		status of lymph node activation as binary variable (no activation vs. activation)