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Riedl, Lydia

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    Research DataOpen Access
    Evaluation zum Workshop "Openness in the Higher Education Classroom – Perspektivenvielfalt für offene Lehre"
    (Philipps-Universität Marburg) Hercher, Sophia; Riedl, Lydia; Binder, Lucie
    Openness umfasst alle Aspekte, die üblicherweise mit Open Science und Open Education assiziiert werden. Es handelt sich um ein Mindset, welches die Öffnung von Forschung und Lehre für die Allgemeinheit anstrebt. Hierbei betrifft Öffnung sowohl enstandenes Material als auch die Teilhabe an der Gestaltung von Bildungsprozessen. Im verknüpften Workshop-Konzept wird die Umfänglichkeit des Konzepts durch einen interdisziplinären Zugang adressiert, welcher durch Mitarbeitende aus Wissenschaft, Bibliothek und E-Learning-Support gemeinsam gestaltet und durchgeführt wird. Hier wird die Evaluation zu diesem Workshopkonzept veröffentlicht und die darauf aufbauenden Anpassungen am Workshopkonzept beschrieben.
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    Research DataOpen Access
    Dopamine D2 receptor antagonism modulates antidepressant placebo effects on reward sensitivity in healthy participants
    (Philipps-Universität Marburg) Augustat, Nick; Lee, Eunhwi; Ahn, Woo-Young; Chuang, Li-Ching; Endres, Dominik; Müller, Erik Malte
    Content: Open code and data for the manuscript "Augustat, N., Lee, E., Ahn, W. Y., Chuang, L. C., Endres, D., Mueller, E.: Dopamine D2 receptor antagonism modulates antidepressant placebo effects on reward sensitivity in healthy participants". Abstract: "Although antidepressant placebo effects are well-known, their underlying mechanisms are not fully understood yet. Given that (i) depression has been related to aberrant dopamine signaling and (ii) placebo effects in Parkinson’s disease have been linked to dopamine, antidepressant placebo effects may likewise be driven by dopamine. More specifically, positive treatment expectations may lead to changes in dopamine and enhance the sensitivity for reward, which is frequently reduced in depression and anhedonia. The goal of this study was to test whether treatment expectations generally affect dopamine-related reward sensitivity in healthy individuals. In a double-blind 2x2 design with N=272 participants, we verbally induced antidepressant treatment expectations (high vs. low), crossed with oral intake of a highly selective dopamine D2/3 receptor antagonist (sulpiride 400mg) vs. placebo. Afterwards, participants performed a probabilistic selection task capturing reward sensitivity, presumably related to dopamine functioning. We performed an extensive computational model fitting procedure, including recovery and comparison of 74 different reinforcement learning models using a hierarchical Bayesian sampling method, to enable a reliable parameter estimation. We found that high treatment expectations increased learning rate in the winning model, which was parametrized by a learning rate, forgetting rate, and inverse temperature. While learning rate was not modulated by sulpiride intake, sulpiride specifically decreased inverse temperature under high treatment expectations. Higher learning rates reflect higher reward sensitivity, while higher inverse temperatures indicate more random choices. Our results thus provide evidence that antidepressant treatment expectations particularly affect reward sensitivity, which is partially modulated by dopamine."